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In vitro PARylation of RSMC was conducted as above in the absence or presence of NAD +

Rossjohn J, McKinstry WJ, Oakley AJ, Verger D, Flanagan J, Chelvanayagam G, et al

This increased permeability allows lipopolysaccharides (LPS), food antigens, and microbial byproducts (PAMPs) to translocate into circulation, triggering systemic immune activation and placing further burden on mast cells 18

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A balanced reading is that the satellite-cell activation hypothesis remains plausible and biologically motivated but is not robustly reproducible across laboratories